Change Image of Image Widget on realtime?

Hello! Is there a way to change the image of an Image Widget during run time? And is there also a way to change it by referencing it from disk? Let’s say I want to use a texture from my C:/Users/…/Desktop/Image/img_01.png folder, is there a way I can reference it from disk to the Image section under the Appearance tab?
reference from disk

download image and dynamic texture and set it to Image